A new drug in development could help you lose weight and keep it off. So far, it’s only been tested on mice, but the prognosis is good: it increases sensitivity to leptin, a hormone that suppresses your appetite.

Obesity substantially increases the risk for a long list of ailments, including heart disease, stroke, high blood pressure, infertility, Alzheimer’s and various cancers. In lieu of a magic pill for now, being mindful of the number of calories you eat and drink, versus the number of calories you burn through physical activities is a great way to decrease your waistline and benefit your health.